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To Codon Optimize or Not: That is the Question


Choosing the most-efficiently-expressed codon from a set of synonyms can improve protein expression rate, but sometimes the stability of the protein depends on a less-efficient expression (for example, one that takes longer, which can sometimes affect the way in which the protein folds).

nonbeard 2021-05-27 21:19:16.318093

MQTT Explorer | An all-round MQTT client that provides a structured topic overview


Quentin's recommendation

nonbeard 2021-05-27 12:30:35.319501

GitHub - ocaml/ocaml-lsp: OCaml Language Server Protocol implementation


OCAML LSP. This worked easily with coc-nvim!

nonbeard 2021-05-24 23:36:07.427520

Using the __cleanup__ variable attribute in GCC — Amit Saha: Technical Writings


Destructor for stack-allocated objects.

nonbeard 2021-05-19 07:34:31.061617

Simulant Shop - Hardware, Computers, Software and Retro computing


Retrocomputer shop in the UK

nonbeard 2021-05-14 20:38:19.539058

Aeromechanics and Evolutionary Morphology | Department of Ecology and Evolutionary Biology | Brown University


nunununununununuBAT LAB

nonbeard 2021-05-13 21:34:04.870256

Speculation Control — The Linux Kernel documentation


>Quite some CPUs have speculation-related misfeatures which are in fact vulnerabilities causing data leaks in various forms even across privilege domains.

>The kernel provides mitigation for such vulnerabilities in various forms. Some of these mitigations are compile-time configurable and some can be supplied on the kernel command line.

>There is also a class of mitigations which are very expensive, but they can be restricted to a certain set of processes or tasks in controlled environments. The mechanism to control these mitigations is via prctl(2).


nonbeard 2021-05-03 12:14:05.825541

What is it like to be boring and myopic?


Kathleen Akins' response to Nagel.

nonbeard 2021-05-02 00:10:24.148300

NNRG Publications


Ristu Miikkulainen's research group at U Texas

nonbeard 2021-05-01 17:57:55.985429

Evolution of neural networks | Proceedings of the Genetic and Evolutionary Computation Conference Companion


More generally, search re using statistical methods instead of random selection for evolution of GAs.

nonbeard 2021-05-01 15:17:51.454914

Autopoiesis - Wikipedia


The term autopoiesis refers to a system capable of reproducing and maintaining itself by creating its own parts and eventually further components.

nonbeard 2021-04-30 14:27:47.138025

[1803.03453] The Surprising Creativity of Digital Evolution: A Collection of Anecdotes from the Evolutionary Computation and Artificial Life Research Communities


Experience paper with various examples of unexpected solutions achieved through evolutionary algorithms.

nonbeard 2021-04-29 15:34:40.270572

Chūnibyō - Wikipedia


Chūnibyō (中二病) is a Japanese colloquial term typically used to describe early teens who had grandiose delusions, who desperately wants to stand out they convinced themselves with hidden knowledge or secret powers. It translates to "second year disease (in Japanese lower secondary school)"

nonbeard 2021-04-29 11:09:03.602603

AirGradient DIY


CO2 and PM2.5 DIY air quality monitor. (HN)

nonbeard 2021-04-28 12:14:49.629427

Laurence Tratt: Fast Enough VMs in Fast Enough Time


An extended talk about RPython. Via HN. To read.

nonbeard 2021-04-26 23:12:00.573998

About Us — Wildtype


":By growing seafood directly from cells, we now have the ability to cultivate genuine salmon and other seafood without relying on wild or farmed fish. "

But $200 for 6 pc of sashimi according to HN.

nonbeard 2021-04-22 19:33:10.115758

Aesthetic Measure — George David Birkhoff | Harvard University Press


This guy answered “What is Beauty?” back in the 1930s.

nonbeard 2021-04-22 00:33:56.546331



立秋, りっしゅう, the first day of Autumn. "The traditional East Asian calendars divide a year into 24 solar terms. [りっしゅう] is the 13th solar term. In the Gregorian calendar, it usually begins around August 7 and ends around August 23." (Wikipedia, abridged)

nonbeard 2021-04-21 12:35:44.261532

The Brain ‘Rotates’ Memories to Save Them From New Sensations | Quanta Magazine

nonbeard 2021-04-17 22:16:07.300259

Book review: "A Thousand Brains" by Jeff Hawkins - LessWrong


Seems like Hawkins has been saying the same thing for 15 years and without much to show.

nonbeard 2021-04-13 21:07:19.515981

Compressing and enhancing hand-written notes


The main trick here is thresholding in HSV space.

Author points at at the end that he still needed to tweak parameters depending on the set of notes he's dealing with. I guess coming up with suitable defaults based on how the notes look might be something that would add value to commercial implementations of this such as Office Lens.

nonbeard 2021-04-12 11:18:08.188132

Shirataki noodles - Wikipedia


translucent, gelatinous traditional Japanese noodles made from the konjac yam.

nonbeard 2021-04-09 22:37:00.274556

Python Releases for Windows | Python.org


I should be using the Python "embeddable package" for Windows, which is smaller than the normal one apparently.

nonbeard 2021-04-09 14:45:33.738949

Ergodicity, what's it mean


"Ergodicity means that the ensemble average is the same as the time average.". Very nice explanation though. (HN)

nonbeard 2021-04-03 18:44:51.246983

Butterick’s Practical Typography

nonbeard 2021-04-03 00:15:33.887000

Docker login using pass credential store


womp womp womp docker credentials

beard 2021-03-29 15:08:10.101353

Five SF Stories in Which Kindness Prevails | Tor.com


Via Bryn

nonbeard 2021-03-21 22:40:04.978672

Entelecheia - definition of Entelecheia by The Free Dictionary


"In the philosophy of Aristotle, the actualization of the potential form or function of a substance."

This is part of the rules for /r/programmingcirclejerk, and I can say that it definitely had the (presumably) desired effect.

nonbeard 2021-03-19 21:56:01.316450

What Is A Tulpa? — Tulpa.io


"A tulpa is an autonomous entity existing within the brain of a “host”. They are distinct from the host in that they possess their own personality, opinions, and actions, which are independent of the host’s, and are conscious entities in that they possess awareness of themselves and the world. A fully-formed tulpa is, or highly resembles to an indistinguishable point, an actual other sentient, sapient being coinhabiting with the host consciousness."


nonbeard 2021-03-13 12:22:00.341063

PMD source analyzer


I'm using it to find duplicates with pmd-bin-6.32.0/bin/run.sh cpd --minimum-tokens 100 --language python --files .

nonbeard 2021-03-11 14:21:59.546366

On repl-driven programming - by mikel evins


The key part of this (at least according to mikel evins) is that you can stop at any point (and in particular at a stack trace), inspect and modify live state including code *and then resume*. Few nonscheme things can do this.

nonbeard 2021-03-10 23:12:17.432493

wmctrl - focus most recent window of an app - Ask Ubuntu


Activating an application cycles through its windows, so this script finds the most recent window by looking at the stack order of the root window. Didn't know this was possible.

nonbeard 2021-03-10 14:48:28.011553

Guest Blogger: Triangular Eating in Japan | Fed Up With Lunch


A way of eating taught to kids to encourage balanced eating in which you eat a portion of each of mains, carbs, vegetables in sequence, then repeat. EG: omlette, rice, salad.

nonbeard 2021-03-09 22:57:29.991860

Punschkrapfen - Austrian recipes


Recipe for essentially petit fours with alcohol, a satisfyingly German name, and a history.

nonbeard 2021-03-09 22:56:42.218903

Anmitsu - Wikipedia


Ancient desert of red bean paste on agar.

nonbeard 2021-03-09 22:35:42.124718

Spinach Puff Pastry Rolls with Feta & Ricotta


This recipe worked really well!

nonbeard 2021-03-09 22:20:28.149071

Weird machines, exploitability, and provable unexploitability


Provides a definition of exploitability in terms of finite state machines: when the real state of the system can not be mapped to any state of the intended system (or an intermediate state when transitioning between any two intended states). Interesting notion of programming as writing an emulator for the IFSM.

nonbeard 2021-02-21 21:51:57

Managing damp problems in old buildings


Very entertaining. "Yet another classic - the surveyor recommended these people have an injection damp proof course installed. Idiot!"

nonbeard 2021-01-31 23:05:09

[Information] Vulnerable Driver Megathread


Collection of signed system drivers that let you read/write privileged memory or expose some other serious vulnerability. If the driver has input buffer validation for IOCTL codes please state so before submitting to the list.

nonbeard 2021-01-15 01:53:24

Okra curry recipe - BBC Food


Okra curry with kashmiri curry masala

nonbeard 2021-01-11 00:58:11

Single hose air conditioners can't cool a room: Convert them to dual hose - Woolie.co.uk


"Background: Air conditioners are just refrigerators with fans"

nonbeard 2020-08-10 23:58:58



GAHoo-deh-teh, GAHoo-deh-teh CHREE-stoos est NAH-toos / ex mah-REE-ah VEER-jee-neh GAHoo-deh-teh

nonbeard 2020-08-03 22:19:47

Small Mailserver Best Current Practices : The Grumpy Troll



beard 2020-07-26 23:22:45

On Moving from Statistics to Machine Learning, the Final Stage of Grief – r y x, r


Really interesting take, via HN, of the difference between statistics and data science -- the former is focused on explaining the parameters, the later is focused on predicting the future. "The big one that made no sense to me the first time I encountered it back in 2017 is that data scientists split their data into “training data,” “validation data,” and “testing data.”"

nonbeard 2020-07-03 10:50:48

Migrate a windows vmware virtual machine to Linux KVM - stafwag Blog


virt-v2v mysteriously disappeared from libvirt-tools recently. This page was helpful -- once I realised that I needed to find the correct snapshot vmdk for the conversion.

nonbeard 2020-06-30 21:24:46

Why Do Dogs Look So Sad? - The Atlantic


"A paper published today in the Proceedings of the National Academy of Sciences found that dogs’ faces are structured for complex expression in a way that wolves’ aren’t, thanks to a special pair of muscles framing their eyes. These muscles are responsible for that “adopt me” look that dogs can pull by raising their inner eyebrows. It’s the first biological evidence scientists have found that domesticated dogs might have evolved a specialized ability used expressly to communicate better with humans." This is quite terrifying.

nonbeard 2020-06-19 16:58:32

occam-pi and KRoC: blending CSP and the pi-calculus


Stuff to read about CSP.

nonbeard 2020-03-20 14:46:52

Developing Brains Fold Like Crumpled Paper to Get Their Convolutions - Scientific American


Brains fold like paper folds. More surface area = more folding. Thicker cortex = less folding. Gyri from in densely-interconnected regions. Sulci form between less-well-connected regions.

nonbeard 2020-03-18 01:36:15

Research on the cerebellum yields rewards | Hacker News

2020-03-11 02:40:57

Setup LAN/WLAN Bridge with OpenWrt (LuCI) (updated) - Nerd Quickies


Loath as I am to bookmark a site called "nerd quickies", this worked as a transparent bridge, except for the firewall part which I had to do by manually editing /etc/config/firewall.

nonbeard 2020-02-07 21:56:49
📜 Boyfriend of Zelda